Inflammatory factors do not enable BMP2-induced osteophyte formation
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چکیده
منابع مشابه
Artemisinin antimalarials do not inhibit hemozoin formation.
The mechanism of action of artemisinin antimalarials may be ascribed to C-centered radicals that alkylate biomolecules or to the peroxide moiety, which inhibits a specific, as yet undefined, target (4). It is also proposed that artemisinins kill the parasite through inhibition of hemozoin formation, thereby allowing buildup of toxic heme monomer (1, 2, 5). Artemisinin and dihydroartemisinin may...
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Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors involved in the cartilage regeneration. However, it also exhibits osteogenic abilities and triggers endochondral ossification. Effective chondrogenesis and inhibition of BMP2-induced osteogenesis and endochondral ossification can be achieved by directing the mesenchymal stem cells (MSCs) towards chondrocyte lineag...
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Design a clocked synchronous state machine with four inputs, G1–G4, that are connected to pushbuttons. The machine has four outputs, L1–L4, connected to lamps or LEDs located near the like-numbered pushbuttons. There is also an ERR output connected to a red lamp. In normal operation, the L1–L4 outputs display a 1-out-of-4 pattern. At each clock tick, the pattern is rotated by one position; the ...
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BACKGROUND Cerium dioxide (CeO(2)) nanoparticles have potential therapeutic applications and are widely used for industrial purposes. However, the effects of these nanoparticles on primary human cells are largely unknown. The ability of nanoparticles to exacerbate pre-existing inflammatory disorders is not well documented for engineered nanoparticles, and is certainly lacking for CeO(2) nanopar...
متن کاملSynovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.
OBJECTIVE In human osteoarthritis (OA), various forms of pathology are observed. Besides cartilage damage and fibrosis, neogenesis of bone, osteophyte formation, also occurs. Osteophytes are thought to limit joint movement and cause pain. The objective of this study was to investigate whether synovial macrophages are involved in osteophyte formation in experimental OA, and if they are, to study...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2016
ISSN: 1063-4584
DOI: 10.1016/j.joca.2016.01.715